Positively selected FimH residues enhance virulence during urinary tract infection by altering FimH conformation
نویسندگان
چکیده
منابع مشابه
Positively selected FimH residues enhance virulence during urinary tract infection by altering FimH conformation.
Chaperone-usher pathway pili are a widespread family of extracellular, Gram-negative bacterial fibers with important roles in bacterial pathogenesis. Type 1 pili are important virulence factors in uropathogenic Escherichia coli (UPEC), which cause the majority of urinary tract infections (UTI). FimH, the type 1 adhesin, binds mannosylated glycoproteins on the surface of human and murine bladder...
متن کاملThe FimH Gene in Uropathogenic Escherichia coli Strains Isolated From Patients With Urinary Tract Infection
BACKGROUND Urinary tract infections (UTIs) are one of main health problems caused by many microorganisms, including uropathogenic Escherichia coli (UPEC). UPEC strains are the most frequent pathogens responsible for 85% and 50% of community and hospital acquired UTIs, respectively. UPEC strains have special virulence factors, including type 1 fimbriae, which can result in worsening of UTIs. O...
متن کاملthe fimh gene in uropathogenic escherichia coli strains isolated from patients with urinary tract infection
conclusions the results of this study indicated that more than 90% of e. coli isolates harbored the fimh gene. the high binding ability of fimh could result in the increased pathogenicity of e. coli; thus, fimh could be used as a possible diagnostic marker and/or vaccine candidate. materials and methods a total of 140 isolated e. coli strains from patients with uti were identified using biochem...
متن کاملAllosteric Coupling in FimH
Background: The bacterial adhesin FimH is allosterically regulated. Results: Mutations designed to control the allosteric state of the protein created low or high affinity variants as predicted. Conclusion: Three regulatory regions are strongly coupled together, while the active site is more weakly coupled to those regions. Significance: Allosteric regulation can be used to develop antiadhesive...
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Background: Urinary tract infections are one of the most frequent health problems and Uropathogenic Escherichia coli is the major pathogen resulting UTIs. The severity of UTIs is caused by the expression of a large range of virulence factors.In this study, we evaluated the allelic frequency fimH gene, in UPECs isolated from patients with UTIs. This study also aimed to determine the roles of C64...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2013
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1315203110